Optical sensing accurately discriminates breast tissue during vacuum-assisted biopsy in ex vivo proof-of-concept

Optical tissue sensing during vacuum-assisted breast biopsy distinguished malignant from healthy tissue with 86% accuracy, 91% sensitivity, 82% specificity in ex vivo study of 40 mastectomy specimens.

• Integration of diffuse reflectance spectroscopy (DRS) into the standard VABB workflow was technically feasible using a novel fiber-equipped introducer, without workflow alteration.
• Patient-wise classification (grouping spectra per specimen) achieved 76% accuracy, 85% sensitivity, and 70% specificity.
• This ex vivo study requires prospective clinical validation to establish diagnostic value.

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