Temporalis muscle texture on brain MRI signals dementia risk across two cohorts

Higher radiomic texture score of temporalis muscle on brain MRI was linked to increased dementia risk (HR per standard deviation: 1.32 in ADNI, 1.64 in ARIC).

• The deep learning model for temporalis muscle segmentation was trained on ADNI and externally validated in ARIC.
• Smaller temporalis muscle cross-sectional area predicted dementia only in ADNI (not ARIC).

Automated summary

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