PET study links late-onset psychosis to Alzheimer’s and tau pathology

PET imaging reveals tau pathology in 65% and amyloid in 35% of patients with psychosis beginning after age 40, vs 15% and 2% in controls, suggesting neurodegenerative disease drives these symptoms.

• Amyloid-negative patients showed tau accumulation in parietal and occipital lobes, indicating non-Alzheimer’s tauopathies.
• Florzolotau (18F) tau PET combined with amyloid PET differentiated Alzheimer’s-related from other neurodegenerative patterns.
• Molecular imaging could enable earlier, more personalized diagnosis and treatment for late-onset psychosis.

Automated summary

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