Brain Age Prediction from MRI Shows Accelerated Aging in Children with Perinatal Stroke

In 105 children with perinatal stroke, brain age prediction from T1 MRI showed accelerated aging (more positive brain age gaps) versus matched controls, especially in arterial ischemic stroke. Motor scores negatively correlated with brain age gaps, with sex-specific differences.

• First study to apply voxel-wise brain age prediction in a pediatric cohort and in perinatal stroke.
• Global and voxel-wise brain age gaps were more positive in stroke, particularly AIS; motor scores negatively correlated with BAGs.
• Sex-specific differences observed in brain age gap correlations with motor outcomes.

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