3D Radiomic Texture Analysis of Quantitative Muscle MRI Enhances Distinction Between Myotonic Dystrophy Type 1 and Charcot-Marie-Tooth Neuropathy Type 1A

3D radiomic texture analysis of quantitative muscle MRI reveals distinct fat infiltration patterns: higher entropy and contrast in Charcot-Marie-Tooth type 1A vs myotonic dystrophy type 1, reflecting reticular vs confluent fat replacement. CMT1A also showed steeper disto-proxima…

• Both patient cohorts showed elevated proton density fat fraction in all lower limb muscles compared to controls (p<0.001).
• Texture analysis revealed higher entropy and contrast, with lower homogeneity in CMT1A, indicating a more reticular pattern of fat infiltration versus the confluent pattern in DM1.
• Proof-of-concept design with 33 patients per group and a single-center setup; findings require validation in broader neuromuscular disease populations.

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