Endothelial Cell Growth Varies Across Metals Used in Aneurysm Devices

In vitro, endothelial cell proliferation on metals used in flow diverters and coils differed: nitinol, stainless steel, and cobalt-chromium supported growth (p<0.001), while platinum and cobalt did not. Smooth muscle cell proliferation was limited. Caution: static conditions.

• Nitinol, nitinol+LTO, 316LVM, and 35NLT showed significantly greater endothelial cell proliferation than platinum and cobalt (all p<0.001).
• Smooth muscle cell proliferation was limited and nonprogressive on most substrates, suggesting restrained neointimal growth.
• These in vitro findings under static conditions require confirmation in flow-based, blood-contacting models.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.