DECT iodine concentration entropy with hybrid-IR or DLIR-M predicts chemo response in PDAC

DECT iodine concentration entropy with hybrid-IR (AUC 0.94) or DLIR-M (AUC 0.91) detects chemo response in PDAC, outperforming DLIR-H (AUC 0.85, P=.02-.04).

• Entropy derived from Hybrid-IR and DLIR-M showed high and comparable diagnostic performance (AUC 0.94 vs 0.91; P = .20).
• DLIR-H reconstruction reduced texture information, leading to a significantly lower AUC (0.85; P = .02–.04 vs others).
• Additional parameters (standard deviation, energy, kurtosis) also significantly differed between response groups.

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