Malignancy risk and CEUS guidance for non-diagnostic peripheral lung biopsies: a multicenter study

In 1591 peripheral lung lesions, CEUS-guided biopsy improved sampling, accuracy, sensitivity vs non-contrast US, especially for 3.1–5.0 cm lesions. Malignancy risk highest for atypical epithelia.

• Approximately 40% of PTNBs yielded non-diagnostic results.
• Malignancy risk was highest with atypical epithelia and lowest with nonspecific benign findings.
• CEUS guidance significantly improved sampling success, accuracy, and sensitivity compared to non-contrast US, especially for 3.1–5.0 cm lesions (all p<0.05).

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