PM2.5 and PM10 exposure linked to elevated pericoronary fat attenuation index on CCTA

Long-term PM2.5 and PM10 exposure correlated with higher pericoronary fat attenuation index on CCTA: each IQR increase in PM2.5 raised right coronary artery FAI by 7.57 HU. Associations strongest in hypertension, diabetes, and smokers.

• Retrospective cohort of 5,528 participants undergoing CCTA, including 656 with serial scans for longitudinal analysis.
• IQR increases in PM2.5, PM10, and black carbon were significantly associated with accelerated annual FAI progression over time.
• Deep-learning pipeline extracted FAI; individual pollutant exposures estimated with 1-km resolution spatiotemporal model.

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