PI-RADS plus PSA density boosts prostate cancer diagnosis over MRI alone

Combining MRI PI-RADS score with PSA density improved prostate cancer detection vs either alone in 187 patients. PI-RADS OR 4.059 (95% CI 2.570-6.412) & log(PSAD) OR 2.743 (1.553-4.845); combined model AUC higher. Retrospective.

• Combined PI-RADS and PSAD model had higher AUC than either alone (DeLong test).
• PI-RADS score (OR 4.059, 95% CI 2.570-6.412) and log(PSAD) (OR 2.743, 95% CI 1.553-4.845) were independent predictors after adjustment.
• Retrospective single-center design with 187 patients limits generalizability.

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