FTIR Spectroscopy and CNNs Uncover Glycan Fingerprint for Malignant Pleural Mesothelioma

FTIR spectroscopy with CNNs reveals a distinct spectral and glycan fingerprint that differentiates malignant pleural mesothelioma from other pleural conditions, identifying two high-mannose N-glycan candidate biomarkers.

• FTIR spectral analysis focused on carbohydrate-related vibrational regions (C-O, C-C stretches, CH2 and C-OH deformations).
• Orthogonal validation by ultra-high-performance liquid chromatography (UPLC) confirmed a unique N-glycome fingerprint for MPM.
• Mass spectrometry (MS) identified two high-mannose N-glycan structures with specific biomarker potential for MPM, requiring future validation.

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