CT Radiomics Augmentation Enhances Classification of Vital vs Non-Vital Neck Nodes After Chemoradiotherapy

In 55 HNSCC patients, a CT radiomics pipeline with feature selection and window contrast augmentation achieved AUC 0.831 for distinguishing vital from non-vital persistent cervical nodes after chemoradiotherapy, an 8.2% relative gain, but differences were not statistically signi…

• Feature selection alone increased the composite score from 0.659 to 0.742.
• The best augmentation strategy was Window Contrast Variation, achieving a composite score of 0.803.
• Individual augmentation gains were not statistically significant in this 55-patient cohort, requiring larger studies.

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