Systematic Review: CT Radiomics Predicts Molecular Subtypes in Clear Cell Renal Carcinoma

CT-based radiomics predicted gene mutations in clear cell renal cell carcinoma with AUC up to 0.987; AUCs range 0.68-0.91. Models also assess hypoxia, immune markers. Multicenter prospective validation needed.

• Systematic review of twenty-five retrospective studies.
• Common machine learning algorithms included Random Forest and Logistic Regression.
• No external validation; authors call for prospective multicenter trials.

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