ASL Cerebral Perfusion Matches FDG-PET in Unresponsive Wakefulness Syndrome

Arterial spin labeling showed decreased cerebral blood flow in patients with unresponsive wakefulness syndrome, consistent with FDG-PET metabolism reductions. Positive correlations occurred globally and in most functional networks, supporting ASL as a noninvasive alternative.

• Prospective study of 33 patients with unresponsive wakefulness syndrome and 17 controls comparing ASL perfusion and FDG-PET metabolism.
• Crossmodal validation using machine learning showed complementary discriminatory information between the two modalities.

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