Optimal MRI Sequence Pairs for Early CKD Detection Found

In early CKD detection, multiparametric MRI combining all four sequences (T1WI, DWI, T1 mapping, BOLD) achieved AUC 0.866. DWI alone had AUC 0.874; T1WI+DWI balanced performance and feasibility (accuracy 0.844, F1 0.815).

• The study prospectively included 105 early CKD patients and 127 healthy controls with a temporally independent test cohort.
• Feature reproducibility was acceptable (ICC 0.731–0.891), and cortical/medullary ADC variability plus corticomedullary ADC difference were consistently retained.
• The model was validated prospectively on a temporally independent cohort, but no external validation was reported.

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