Fluid-suppressed mean diffusivity reveals low ADC regions obscured by free water in gliomas

In 60 brain tumor patients, a new fluid-suppressed diffusivity map outperformed ADC for visualizing reduced diffusion, and was significantly linked to IDH status.

• High b-value spherical b-tensor encoding enabled free water suppression, improving detection of low-diffusivity regions.
• IDH wildtype (glioblastoma) patients showed more areas where tissue diffusivity was lower than ADC, and tissue diffusivity was significantly associated with IDH status.

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