Multimodal PET/MRI fusion with novel tracers and AI coregistration advances epileptogenic zone localization

A review proposes a shift from FDG-PET to multimodal molecular-structural fusion using novel PET tracers targeting synaptic density, neuroinflammation, and neurotransmitter systems, integrated with isotropic 3D MRI and AI coregistration, to improve surgical localization of epile…

• Novel PET radiotracers target proximal pathophysiology: SV2A (synaptic density), TSPO (neuroinflammation), GABA_A, mGluR5, and AMT.
• Clinical evidence suggests enhanced detection of subtle lesions, refined surgical boundaries, and optimized SEEG trajectory planning.
• Integration with isotropic 3D MRI and AI-driven coregistration pipelines enables precise molecular-structural coupling.

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