Graph-Based Tractometry Lacks Validation Infrastructure Despite Modest Gains, Review Warns

Graph-based white matter tractometry preserves spatial topology and detects distributed pathology patterns. A systematic maturity assessment finds modest improvements over traditional methods, but comprehensive benchmarking against TBSS and AFQ is absent, and validation platform…

• Where controlled comparisons exist, graph methods show modest improvements over traditional along-tract profiles.
• Comprehensive benchmarking against tract-based spatial statistics (TBSS) and automated fiber quantification (AFQ) has not been performed.
• Dedicated validation platforms for tractometry detection models do not yet exist, hampering clinical translation.

Automated summary

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