Combined clinical and MRI peritumoral habitat radiomics model achieves AUC 0.921 for stage IA endometrial cancer

A peritumoral MRI habitat radiomics model combined with clinical data differentiated stage IA endometrial cancer from benign lesions with peak AUC 0.921, and raised external validation AUC from 0.644 to 0.850 in a multicenter study.

• The combined model yielded peak AUC 0.921, significantly improving upon the clinical-only AUC of 0.644 in a challenging external subset.
• Peritumoral habitat features (K-means_RD3) showed robust average external validation AUC of 0.740, exceeding intratumoral models.
• K-means clustering demonstrated superior stability compared to Gaussian Mixture Model.

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