Myocardial T1 mapping in 27,794 adults reveals sex differences and cardiometabolic risk associations

In a population-based CMR study of 27,794 adults, myocardial native T1 was higher in women (1,231±33 ms) than men (1,209±34 ms), with associations differing by sex for hypertension. Diabetes, kidney disease, and smoking were linked to higher T1; hyperlipidemia to lower T1.

• Women had higher native T1 than men (1,231±33 vs 1,209±34 ms), with the sex difference progressively declining with age.
• Diabetes, kidney disease, and current smoking were significantly associated with higher T1, while hyperlipidemia was associated with lower T1.
• Hypertension showed sex-specific patterns: lower T1 in women, higher T1 with increasing severity in men.

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