Body / AbdominalAI / InformaticsResearch
Multimodal model combining CT radiomics and transcriptomics predicts survival in gastric cancer after neoadjuvant therapy
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Associationtoday
Multimodal model integrating CT radiomics, transcriptomics and clinical data predicted OS (C-index 0.855) and DFS (C-index 0.786) in gastric cancer after neoadjuvant therapy, outperforming single-modality models and ypTNM staging.
- Radiomic risk from preoperative CT (HR 4.0, P<0.001) and molecular risk from transcriptomic sequencing (HR 7.1, P<0.001) were independent prognostic factors.
- The model was built on 505 patients with external validation, integrating six radiomic and three molecular features.
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