Dopamine D2 receptor loss on PET shows no link to education or leisure activities in older adults

In 181 healthy older adults, 5-year decline in dopamine D2-like receptor availability on [11C]raclopride PET showed only weak correlations with cognitive decline, and no link to education or leisure activities.

• DRD2 availability declined in caudate and putamen over 5 years.
• Associations between DRD2 changes and education or leisure activities were negligible.
• Education or leisure activities did not moderate the DRD2-cognition change correlations.

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