Combined plasma p-tau217 and hippocampal/amygdalar MRI volumes predict amyloid-β in MCI

Multimodal model using plasma p-tau217, Aβ42/Aβ40, APOE4, MMSE, and hippocampal/amygdalar MRI volumes predicted amyloid-β positivity with AUC 0.875 (internal) / 0.883 (external) in mild cognitive impairment, outperforming single-modality models. Predicted risk stratified progres…

• The optimal logistic regression model incorporated APOE ε4 status, Mini-Mental State Examination score, plasma p-Tau217, Aβ42/Aβ40 ratio, and bilateral hippocampal and left amygdalar volumes.
• Model-derived Aβ risk probability stratified disease progression risk in MCI patients in an independent longitudinal cohort (C-index = 0.771).

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