Hematoma Clotting Linked to Perihematomal Edema in Acute ICH

In acute ICH, clot volume on QSM correlated with edema (T3 r=0.80, p<0.001), independent of hematoma size (partial r=0.554, p=0.021). Coagulation may increase edema, relevant for procoagulant therapy.

• Hematoma volume was also significantly associated with perihematomal edema at all times, and remained independent after adjusting for clot blood volume.
• Both clot blood volume and edema volume increased significantly from first to last MRI within 72h (CBVol: 3.21 to 5.58 mL, p=0.0007; edema: 22.6 to 31.5 mL, p=0.005).

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