Coronary plaque quantification reproducibility between EID and photon-counting CT: power modeling for mixed-platform trials

Optimized reconstruction (Qr40 EID-CT vs Bv36 PCD-CT) yielded inter-scanner SD of 0.12 (patient-based). At 80% power, detecting a 10% change in total plaque volume requires 23 patients per group; 5% change needs 92 patients.

• Strong inter-scanner correlations for plaque components (r=0.71–0.98) and optimal reconstruction pair (Qr40 EID-CT vs Bv36 PCD-CT) yielded lowest inter-scanner SD (0.14 vessel-based, 0.12 patient-based).
• Sample sizes to detect 10% and 5% total plaque volume change at 80% power: 23 and 92 patients per group, respectively.

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