Automated CT Midline Shift Measurement Matches Expert Accuracy in Multicenter Study

Rapid MLS automated midline shift quantification on noncontrast CT matched expert neuroradiologists (mean absolute error 0.8 vs 0.9 mm, p<0.0001) in a multicenter study of 153 patients with intracranial pathology. The tool slightly underestimated shifts >10 mm.

• Multicenter retrospective study with 153 patients from 13 centers, using three neuroradiologists' consensus as reference.
• Passing-Bablok regression showed agreement (intercept 0.29, slope 0.9); Bland-Altman mean difference 0.2 mm.
• Rapid MLS underestimated MLS values above 10 mm.

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