Lipidomic shifts and faster biological aging tied to coronary microvascular dysfunction

Patients with coronary microvascular dysfunction had an older PhenoAge (61 vs 52 years) and dysregulated triacylglycerol lipids. Adding lipid species to clinical factors improved prediction (AUC 0.94 vs 0.86).

• Among 43 angina patients without epicardial stenosis, 25 had CMD defined by angiography-derived IMR >25.
• Six independent risk factors were identified: PhenoAge, triglyceride-glucose index, hypertension, and three specific lipid species.
• This small case-control study requires larger-scale external validation before clinical translation.

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