Stress CMR ischemic burden predicts long-term mortality in LV systolic dysfunction

In 5,977 patients with LVEF <50%, each ischemic segment on stress perfusion CMR independently raised long-term mortality (HR 1.11 per segment, 95% CI 1.06–1.15). Adding ischemia and LGE to clinical factors and LVEF improved risk prediction (NRI 0.217, p<0.001) over 9 years media…

• Inducible ischemia was present in 19% of patients (mean extent 2.4±1.2 segments); 22% (1,343 patients) died during follow-up.
• The prognostic value of ischemia extent was consistent across LVEF subgroups (40–50% and <40%).
• This is a prospective multicenter registry study from three French centers (2008–2024) with multivariable Cox modeling.

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