Weight Cycling Linked to Greater Thigh Muscle Volume Loss on MRI Over 48 Months

In weight-stable adults, weight cyclers had greater thigh muscle volume loss on MRI over 48 months (−3.71% vs −1.03%, P=.003) than noncyclers, with no difference in intermuscular adipose tissue or knee subcutaneous fat changes.

• Weight cyclers (n=77) showed significantly greater loss of thigh muscle volume compared to noncyclers (n=1356) over 48 months.
• Changes in intermuscular adipose tissue proportion and knee subcutaneous fat thickness were similar between groups.
• The analysis included 1433 participants from the Osteoarthritis Initiative with stable weight (<5% cumulative change).

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