Feasibility of Dog and Pig Models for Hepatospecific MRI Contrast Kinetics Using DCE-MRI

Feasibility study in dogs and a pig shows hepatospecific MRI contrast enhancement dynamics and pharmacokinetic estimates resembling human data, supporting translational models. Single-input DCE-MRI detected significantly higher hepatocyte uptake rates for gadoxetate and gadobena…

• Dogs showed rapid hepatic enhancement plateau after gadoxetate; pig showed rapid rise, blunt peak, then gradual decline for both hepatospecific agents.
• Single-input reference region model confirmed higher uptake rates for hepatospecific agents; dual-input model effectively distinguished contrast dynamics.
• Definitive comparison to humans requires direct paired evaluation under matched conditions (study limitation).

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