Elastin-specific molecular MRI tracks cyclodextrin therapy effect in mouse aortic aneurysms

In a mouse model of abdominal aortic aneurysm, cyclodextrin-treated mice showed significantly smaller aortic areas (2.31 vs 2.96 mm², p=0.018) and lower elastin-specific MRI enhancement (1.56 vs 2.15, p=0.038), indicating preserved aortic wall integrity, while macrophage imaging…

• Elastin-specific molecular MRI non-invasively monitored cyclodextrin's therapeutic effect on extracellular matrix integrity.
• USPIO-based macrophage imaging showed no significant difference between groups (p=0.441), consistent with limited inflammatory modulation under study conditions.
• This dual-probe approach highlights the potential of tracking matrix preservation as a treatment response marker in aortic aneurysm.

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