CT dose, not FDG, drives chromosomal aberrations in PET/CT: prospective study

In a prospective study, standard-dose CT during PET/CT significantly increased chromosomal aberrations (p=0.016), while reduced-dose CT and FDG injection did not. CT effective dose was independently associated with aberration frequency, supporting protocol optimization.

• Standard-dose CT significantly increased chromosomal aberrations (p=0.016), while reduced-dose CT and FDG injection did not.
• CT effective dose, but not FDG effective dose, was independently associated with aberration frequency after multivariable adjustment.
• Age and prior chemotherapy also influenced aberration frequency, reinforcing the biological rationale for dose optimization.

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