Tau PET tracer PI-2620 links temporal lobe binding to plasma p-tau217 and memory decline in cognitively unimpaired older adults

In 166 cognitively unimpaired older adults, higher temporal lobe [18F]PI-2620 tau PET binding was associated with higher plasma p-tau217 (β=0.22), worse episodic memory (β=-0.36), female sex, and APOE4 carrier status. These brain and blood markers explained ~30% of memory varian…

• Temporal [18F]PI-2620 binding was significantly higher in women (β=0.543, P<0.001) and APOE4 carriers (β=0.395, P=0.030).
• In a multiple regression model, both higher temporal DVR (β=-0.36, P=0.003) and lower hippocampal volume (β=0.22, P=0.007) independently predicted worse episodic memory.
• Voxelwise analyses revealed age-related signal increases in the basal ganglia, while white matter signal was paradoxically higher in younger adults, suggesting the need to consider potential off-target binding.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.