High Myopia Alters Brain Asymmetry and Halves Interhemispheric Link, Tied to Serotonin

In high myopia, resting-state fMRI shows stronger within-hemisphere autonomy in the right lingual gyrus but weaker interhemispheric synergy between bilateral fusiform gyri. These altered brain areas strongly match serotonin/dopamine receptor maps. A classifier using interhemisph…

• A support vector machine classifier using interhemispheric functional connectivity features distinguished high myopia from controls with 72.73% accuracy (AUC = 0.72).
• The anomalous functional regions demonstrated a robust spatial correlation with the density distribution of serotonin and dopamine receptors and acetylcholine transporters.

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