Multiphase CCTA velocimetry quantifies coronary flow velocity with <4% mean in vitro error

In vitro, multiphase CCTA velocimetry (VBMPI) achieved <4% mean error in coronary flow velocity quantification across stenosis severities. In 5 patients, velocity ratio showed promise for stenosis characterization and ischemia detection (preliminary, not yet clinically validated…

• In vitro phantom study using 3D-printed coronary replicas with multiple stenosis severities and heart rates; validated against CFD and 4D flow MRI; optimal parameters defined.
• Mean flow velocity deviation below 4% (max <9%) across all RCA replicas; stenotic-to-proximal velocity ratio emerged as exploratory ischemia indicator.
• Pilot in vivo assessment in 5 patients showed consistency with DSA for stenosis severity and qualitative agreement with deep-learning-derived FFR.

Abstract-only summary; full study with limited in vivo sample (n=5) not independently reviewed.

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