Systematic Review: AI Models Strongly Detect Mandibular Canal–Third Molar Relationship on CBCT and Panoramic Radiographs

AI assessment of mandibular canal–third molar relationship on CBCT/panoramic radiography achieves accuracy 80–97%, AUC 0.84–0.98 across 29 studies; however, lack of external validation limits clinical deployment.

• Systematic review of 29 diagnostic-accuracy studies (15 panoramic radiography, 9 CBCT, 5 both).
• Reported sensitivity and specificity commonly exceeded 85%; AUC ranged 0.84–0.98.
• Interpretation is limited by methodological heterogeneity and absence of prospective external validation.

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