Combined MRI Radiomics-Clinical Model Yields AUC 0.867 for Prostate Cancer in PSA 4–10, PI-RADS 3 Cohort

Combined MRI radiomics-clinical model AUC 0.867 for prostate cancer in men with PSA 4–10 ng/mL and PI-RADS 3, vs radiomics-only AUC 0.833, clinical-only AUC 0.767. Retrospective 93 patients.

• Retrospective study of 93 patients with PSA 4–10 ng/mL and PI-RADS score 3.
• Best radiomics model (DWI_T2 fusion, ExtraTrees) achieved validation AUC 0.833 (95% CI 0.662–1.000), F1 0.778; clinical model (RandomForest) AUC 0.767 (95% CI 0.561–0.973).
• Combined logistic regression model gave AUC 0.867, but no 95% CI reported; limited by small single-center cohort and no external validation.

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