AI-Driven Discovery of Rosmarinic Acid as a Ferroptosis Inhibitor for Ulcerative Colitis via ALOX15-VDAC1

An AI machine-learning model identified rosmarinic acid as a novel ALOX15 inhibitor. In a mouse model of colitis, it reduced disease activity, histological damage, and barrier protein loss by suppressing ferroptosis through the ALOX15-VDAC1 axis.

• Design: Preclinical study using machine learning for drug discovery, validated in a dextran sulfate sodium-induced mouse colitis model and in vitro on intestinal epithelial cells (full n not reported).
• Key finding: Rosmarinic acid disrupted the ALOX15-VDAC1 protein complex restoring ferroptosis markers GPX4 and SLC7A11, with effects abrogated by ALOX15 or VDAC1 knockdown.
• Limitation: Preclinical validation in animal and cell-line models only; therapeutic efficacy and safety in human ulcerative colitis patients have not been established.

RadPigeon summaries are original and for information only. They are not clinical advice.