Preoperative hippocampal and precuneal ReHo reductions on fMRI predict delirium after cardiac surgery

Patients who developed postop delirium after valve surgery had reduced preoperative ReHo in left hippocampus, precuneus, and rolandic operculum. An SVM model using these features and age discriminated cases (n=35, 7 events, prospective).

• Prospective cohort of 35 patients undergoing valve replacement; 7 (20%) developed postoperative delirium.
• SVM discrimination of delirium used preoperative ReHo and age (exact accuracy/AUC not reported); reduced hippocampal ReHo correlated with cardiac function, rolandic operculum ReHo with episodic memory.
• Major limitation: very small sample, no external validation.

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