Substantia Nigra Radiomics on Neuromelanin-MRI Differentiates Bipolar II from Unipolar Depression

Radiomic analysis of neuromelanin-sensitive MRI substantia nigra distinguished bipolar II from unipolar depression: SVM AUC 0.812, specificity 80.6% in leave-one-out cross-validation. Single-center study in 126 drug-naïve patients, external validation needed.

• Secondary analysis of 126 drug-naïve patients (46 BD-II, 38 UD, 42 HCs) using neuromelanin-sensitive MRI.
• SVM model for BD-II vs UD: AUC 0.812 (95% CI 0.720–0.905), specificity 80.6% vs. logistic regression 67.7%.
• Limitations: single-center, no external validation, small sample, only internal LOOCV.

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