Multiphase MRI Radiomics Predicts Early HCC Progression: Multicenter Study Shows Moderate Accuracy

Multiphase MRI radiomics integrating tumor and peritumoral features predicted early progression in HCC: external validation AUC 0.77, C-index 0.65, HR 1.56 (p=0.05) for high-risk group. Retrospective, multicenter.

• Multicenter retrospective study of 249 HCC patients treated with resection or TACE; built a multiphase radiomics model (MP-RM) using arterial, portal venous, and subtraction delta phases.
• MP-RM outperformed single-phase models (training AUC 0.819, C-index 0.774; external AUC 0.774, C-index 0.653).
• Limitation: retrospective design without prospective external validation; potential selection bias from heterogeneous treatments.

RadPigeon summaries are original and for information only. They are not clinical advice.