Deep Learning Creates Whole Mouse Brain Neuron Atlas from High-Res MRI

Deep learning using diffusion MRI and light-sheet microscopy generated a whole-brain neuronal cell-type atlas of the adult mouse brain at 10 µm isotropic resolution, registered to the Allen Mouse Brain Common Coordinate Framework.

• Multimodal framework integrated high-resolution dMRI with 3D light-sheet microscopy and registered to the Allen Mouse Brain atlas.
• Correlated dMRI metrics with spatial transcriptomics-derived cell types to train a deep learning model for predicting neuronal subtypes.
• Limitation: single-species mouse study; translational potential to human brain cell-type mapping remains to be validated.

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