Combined MRI Radiomics Adds Little Over Single-Compartment Models for HCC Microvascular Invasion Prediction

A meta-analysis of 13 studies (N=3173) finds combined intratumoral-peritumoral MRI radiomics models achieve a pooled AUC of 0.83 for predicting microvascular invasion in hepatocellular carcinoma. The incremental benefit over intratumoral-only (AUC 0.78) or peritumoral-only (AUC…

• Systematic review and meta-analysis of 13 retrospective studies totaling 3173 patients with histopathological reference standards.
• Combined models yielded AUC 0.83 (95% CI: 0.80-0.87); delta AUC vs. peritumoral-only was 0.05 (p=0.110) and vs. intratumoral-only was 0.05 (p=0.097).
• Studies with external validation showed lower AUCs than internally validated ones, suggesting optimism bias; prospective multicenter validation with standardized protocols is needed.

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