Cardiac MRI Entropy Independently Predicts Major Events in Acute Myocarditis

In a multicenter study of 492 acute myocarditis patients, left ventricular (LV) global entropy ≥8.5 on cardiac MRI independently tripled the risk of major adverse cardiovascular events (hazard ratio 3.33). Late gadolinium enhancement entropy also remained an independent predicto…

• Retrospective study with 492 patients: 319 in a discovery cohort and 173 in an external testing cohort from two other centers.
• Adding LV global entropy to a baseline model (including LV ejection fraction and LGE extent) significantly improved model fit for predicting major adverse cardiovascular events (χ2 66.88 vs 77.47; P < .001).
• Limitation includes the retrospective design, requiring prospective validation before routine clinical integration.

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