Scoping review finds only four small studies on Pacinian corpuscle changes in diabetic foot, evidence too sparse for clinical standards

A scoping review found only 4 small studies on Pacinian corpuscle distribution in diabetic foot; both histology and MRI can detect them, but evidence is too sparse to establish reference standards for clinical use.

• Scoping review following PRISMA guidelines, searching 6 databases (2015–2026), included just 1 case report, 1 experimental, 1 morphometric, and 1 combined retrospective–prospective study with small sample sizes.
• Both histological quantification and MRI can detect Pacinian corpuscles and may support early neuropathy detection, but data are insufficient to define normal or pathological ranges.
• Critical limitation: extremely limited evidence base with heterogeneous, small studies; no reliable reference standards exist for Pacinian corpuscle density in health or diabetes.

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