Cryoablation of Endophytic Renal Tumors Tied to Early, But Not Late, eGFR Decline

Cryoablation of endophytic renal tumors caused an early 7.1 mL/min/1.73m² eGFR drop vs 2.4 for exophytic (p=0.003). CKD stage progression was higher at 1 year (p=0.01), but 3-year decline and CKD progression were comparable between groups.

• Design: Retrospective, single-center review of 450 procedures in 392 patients, analyzed using propensity-score matched cohorts of 89 endophytic vs 89 exophytic tumors.
• At 1 year, more endophytic patients progressed to CKD Stage 3b or higher (10/76 vs 1/71, p=0.01). By 3 years, difference was not significant (7/65 vs 6/68, p=0.78).
• Limitation: Retrospective, single-center design with potential for residual confounding and selection bias.

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