Future of [18F]FDG PET: From Regional Reads to Network-Based, Dynamic, and Computational Biomarkers

[18F]FDG PET is shifting from regional interpretation to network-based and computational analyses for individualized brain dysfunction assessment. Dynamic and total-body PET add temporal physiology and brain-body interaction data. Clinical impact hinges on developing standardize…

• Design: This is a 'Future Directions' perspectives/review article, not a primary research study with a patient cohort or statistical results.
• Key trend: Emerging network-based and computational models aim to make [18F]FDG PET reports more explicit and individualized, moving beyond simple regional hypometabolism patterns.
• Key trend: Dynamic and total-body PET imaging are expanding the modality's capability to assess temporal physiology and systemic brain-body interactions, respectively.

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