Microbiota-gut-brain axis in autism linked to brain MRI changes

Narrative review finds gut microbiome dysbiosis in ASD linked to brain structural/functional MRI changes. Microbiota-targeted interventions show promise but evidence is insufficient for clinical application. Standardized multicenter imaging-omics studies needed.

• Review synthesizes clinical and translational studies on microbiota-gut-brain axis in ASD.
• Three core signaling routes: microbial metabolites, immune-mediated, neuroendocrine-vagal.
• Integrating multimodal neuroimaging with multi-omics and machine learning may yield biomarkers for early detection and stratification.

Abstract only; full review and underlying primary studies not verified.

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