Brain MRI Features Improve ML Prediction of Postoperative Nausea After Lung Resection

ExtraTrees classifier integrating brain MRI features with clinical data predicted postoperative nausea/vomiting after lung surgery (AUROC 0.82 internal, 0.80 external validation), outperforming the Apfel score. Interpretable model highlighted reduced cortical curvature in visual…

• Retrospective study in 416 lung resection patients; internal and external validation performed. Optimal model: ExtraTrees classifier.
• Key neuroanatomical predictors: reduced left parieto-occipital curvature, decreased right occipital pole curvature/cuneus folding, plus female sex.
• Main limitation: retrospective design, single-center data; needs prospective validation in larger cohorts.

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