Non-FDG PET Radiotracers Offer Complementary Insights for Epilepsy Presurgical Evaluation

Non-FDG PET radiotracers targeting neuroreceptors, synaptic density, and neuroinflammation may improve localization of the epileptogenic zone beyond glucose metabolism. Currently mostly research, advancing development could enhance clinical utility.

• Comprehensive review of non-FDG PET radiotracers for epilepsy presurgical evaluation, summarizing targets (receptors, transporters, synaptic density, neuroinflammation) and clinical applications.
• Most tracers remain predominantly in the research setting; advancing radiotracer development may increase clinical applicability in the future.
• Review lacks primary data or meta-analytic synthesis; conclusions based on qualitative summary of literature.

RadPigeon summaries are original and for information only. They are not clinical advice.